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KMID : 0811720040080000193
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Korean Journal of Physiology & Pharmacology
2004 Volume.8 No. 0 p.193 ~ p.0
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Suppression of IgE Production and Modulation of Th1/Th2 Cell Response by Electroacupuncture in DNP-KLH Immunized Mice
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Park Moon-Baik
Ahn Chang-Joon
Shin Min-Kyu
Hong Moo-Chang
Min Byung-Il
Bae Hyun-Su
Rho Sam-Woong
Ko Eun-Jung
Choi Hyun
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Abstract
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Effects of electroacupuncture (EA) on Th1/Th2 cell response were investigated in BALB/c mice immunized intraperitoneally with 2,4-dinitrophenylated keyhole limpet protein (DNP-KLH). Successive electroacupuncture stimulation on the ST36 acupoint was performed just after immunization. Serum levels of antigen-specific IgE and total IgE were significantly decreased compared with non-acupunctured controls. Production of the Th2-specific cytokines IL-4 and IL-13 in the anti-CD3 mAb- activated splenocytes was significantly suppressed in ST36 electroacupunctured mice compared with non-acupunctured mice. These results imply that successive electroacupuncture on ST36 can decrease the serum level of antigen-specific IgE and total IgE by suppression of the Th2 lineage development.
Source: Korean Journal of Physiology & Pharmacology.2004 Oct;8(Suppl I):S141-S141
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KEYWORD
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Acupuncture, Th2, DNP-KLH, IgE, ST36
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